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IMMUNOGLOBULIN J-CHAINS
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DeCS
Descriptor
English
:
Immunoglobulin J-Chains
Descriptor
Spanish
:
Cadenas J de Inmunoglobulina
Descriptor
Portuguese
:
Cadeias J de Imunoglobulina
Synonyms
English
:
J-Chains, Immunoglobulin
Tree Number:
D12.776.124.486.485.705.625
D12.776.124.790.651.705.625
D12.776.377.715.548.705.625
Definition
English
:
A 15 kD "joining" peptide that
forms
one of the linkages between monomers of
IMMUNOGLOBULIN A
or
IMMUNOGLOBULIN M
in the formation of polymeric
immunoglobulins
. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric
immunoglobulins
to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the
IMMUNOGLOBULIN JOINING REGION
which is part of the
IMMUNOGLOBULIN VARIABLE REGION
of the immunoglobulin
light
and heavy chains.
Pharmacological Action:
Immunologic Factors
See Related
English
:
Immunoglobulin A
Immunoglobulin M
History Note
English
:
2006 (1974)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
30363
Unique Identifier:
D007144
Occurrence in VHL
:
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